The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Jul. 16, 2015
Tgif2-induced reprogramming of hepatic cells to pancreatic progenitor cells and medical uses thereof
Applicant:
Max-delbrueck-centrum Fuer Molekulare Medizin, Berlin, DE;
Inventors:
Francesca Spagnoli, Berlin, DE;
Nuria Cerda-Esteban, Berlin, DE;
Assignee:
MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN, Berlin, DE;
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 5/02 (2006.01); C12N 5/071 (2010.01); A61K 35/39 (2015.01); A01K 67/027 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0678 (2013.01); A01K 67/0276 (2013.01); A61K 35/39 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2267/0362 (2013.01); C12N 2501/60 (2013.01); C12N 2501/70 (2013.01); C12N 2506/14 (2013.01); C12N 2510/00 (2013.01); C12N 2740/16043 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01); C12N 2830/008 (2013.01);
Abstract
Disclosed are genetically modified human pancreatic progenitor cells having an exogenous nucleic acid molecule encoding TGIF2, for use as a medicament in the treatment of a subject with diabetes. In addition methods for the production of such cells are described. Also disclosed is an expression vector encoding TGIF2 for use as a medicament in the treatment of a subject with diabetes.