The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 07, 2020

Filed:

Nov. 12, 2018
Applicant:

Grunenthal Gmbh, Aachen, DE;

Inventors:

Mazen Hanna, Lutz, FL (US);

Ning Shan, Chandler, AZ (US);

David R. Weyna, Tampa, FL (US);

Miranda L. Cheney, Northborough, MA (US);

Assignee:

THAR PHARMA, LLC, Pittsburgh, PA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/6506 (2006.01); C07C 229/22 (2006.01); C07C 229/24 (2006.01); A61K 9/00 (2006.01); A61P 35/04 (2006.01); A61P 19/10 (2006.01); A61P 3/14 (2006.01);
U.S. Cl.
CPC ...
C07F 9/6506 (2013.01); A61P 3/14 (2018.01); A61P 19/10 (2018.01); A61P 35/04 (2018.01); C07C 229/22 (2013.01); C07C 229/24 (2013.01); A61K 9/0053 (2013.01); C07B 2200/13 (2013.01);
Abstract

The invention relates to the preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid. The invention also relates to the use of the novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid in pharmaceutical compositions in drug delivery systems for humans. The invention further relates to the use of the novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid or the pharmaceutical compositions thereof to treat and/or prevent a disease state associated with osteoporosis, tumor induced hypercalcemia (TIH), cancer-induced bone metastasis, Paget's disease or for adjuvant or neoadjuvant therapies.


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