The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Nov. 19, 2015
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Viviane Tabar, New York, NY (US);
Kosuke Funato, Astoria, NY (US);
Assignee:
Memorial Sloan-Kettering Cancer Center, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/04 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01); C12N 5/0797 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61K 31/519 (2013.01); A61P 35/00 (2018.01); C12N 5/0623 (2013.01); G01N 33/5011 (2013.01); C12N 2503/02 (2013.01); C12N 2510/00 (2013.01);
Abstract
Described herein are thienopyrimidine compounds of Formula (I), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the thienopyrimidine compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., brain tumors such as DIPGs) in a subject. The invention further provides an embryonic stem cell-based tumor cell model, which can be used for drug screening and disease target identification.