The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
May. 02, 2016
Applicant:
Parion Sciences, Inc., Durham, NC (US);
Inventors:
Michael Ross Johnson, Chapel Hill, NC (US);
William R. Thelin, Chapel Hill, NC (US);
Assignee:
PARION SCIENCES, INC., Durham, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/265 (2006.01); C07C 327/36 (2006.01); C07C 327/28 (2006.01); C07C 327/22 (2006.01); C07C 323/16 (2006.01); C12P 19/60 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C12P 17/16 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 31/047 (2006.01); A61K 31/133 (2006.01); A61K 31/341 (2006.01); A61K 31/385 (2006.01); A61K 31/683 (2006.01); A61K 33/14 (2006.01); C07D 307/68 (2006.01); C07D 339/00 (2006.01); C07D 339/08 (2006.01); C07F 9/6578 (2006.01); C07C 321/20 (2006.01); C07D 241/12 (2006.01); C07C 329/12 (2006.01); C07D 307/64 (2006.01);
U.S. Cl.
CPC ...
C07C 327/28 (2013.01); A61K 9/0075 (2013.01); A61K 9/16 (2013.01); A61K 31/047 (2013.01); A61K 31/133 (2013.01); A61K 31/265 (2013.01); A61K 31/341 (2013.01); A61K 31/385 (2013.01); A61K 31/683 (2013.01); A61K 33/14 (2013.01); C07C 321/20 (2013.01); C07C 323/16 (2013.01); C07C 327/22 (2013.01); C07C 329/12 (2013.01); C07D 241/12 (2013.01); C07D 307/64 (2013.01); C07D 307/68 (2013.01); C07D 339/00 (2013.01); C07D 339/08 (2013.01); C07F 9/6578 (2013.01); C07F 9/65785 (2013.01); C12N 9/0071 (2013.01); C12N 9/0073 (2013.01); C12N 9/1051 (2013.01); C12N 9/13 (2013.01); C12P 17/165 (2013.01); C12P 19/60 (2013.01); C12Y 114/13008 (2013.01); C12Y 114/14001 (2013.01); C12Y 208/02001 (2013.01); Y02A 50/406 (2018.01);
Abstract
Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.