The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Oct. 11, 2018
Wisconsin Alumni Research Foundation, Madison, WI (US);
Helen Blackwell, Middleton, WI (US);
Daniel Manson, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
Modulation of quorum sensing in Gram-negative bacteria, particularly strains ofwhich form biofilms, by compounds including those of formula I and formula II: where:AR is optionally substituted phenyl, cycloalkyl or cycloalkenyl or heterocyclic, and Ris optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkylthioalkyl or alkyl substituted at the omega position with optionally substituted phenyl, cyclohexyl or cyclohexenyl. In particular compounds inhibit quorum sensing and biofilm formation. Pharmaceutical compositions for treatment of bacterial infections and methods of treatment of such infections are provided.