The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 07, 2020

Filed:

Feb. 06, 2018
Applicant:

Huazhong University of Science and Technology, Hubei, CN;

Inventors:

Shengmin Zhang, Hubei, CN;

Yan Li, Hubei, CN;

Hang Hao, Hubei, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 27/50 (2006.01); A61L 27/42 (2006.01); A61L 27/16 (2006.01); C01B 25/32 (2006.01);
U.S. Cl.
CPC ...
A61L 27/50 (2013.01); A61L 27/16 (2013.01); A61L 27/425 (2013.01); C01B 25/327 (2013.01); C01P 2002/54 (2013.01); C01P 2002/70 (2013.01); C01P 2002/72 (2013.01); C01P 2002/82 (2013.01); C01P 2004/03 (2013.01); C01P 2004/04 (2013.01); C01P 2004/16 (2013.01);
Abstract

The invention relates to a selenium-doped hydroxyapatite and a preparation method thereof. The selenium-doped hydroxyapatite provided is a single crystal comprising a rod-like structure, a uniform morphology, and a good dispersibility. The preparation method comprises adding a mixed solution of a phosphate and a selenite dropwise to a mixed solution of a calcium salt and a dispersing agent, and reacting for 1.5-2.5 hrs at a controlled temperature of 80-90° C., to obtain a solution of a calcium phosphate amorphous precursor, followed by performing a hydrothermal reaction at 190-210° C., to obtain a selenium-doped hydroxyapatite comprising a rod-like structure. Compared with selenium-doped hydroxyapatite with severe agglomeration, the selenium-doped hydroxyapatite provided in the present invention comprises good dispersibility and able to have better prevention of clogging problem in human body when in use, thus having a good prospect using as a multi-functional new material for bone repair in patients as a repair material for bone defects, an anti-tumor, etc.


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