The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Apr. 16, 2019
Tijana Rajh, Naperville, IL (US);
Elena A. Rozhkova, Lemont, IL (US);
Harry C. Fry, Lincolnwood, IL (US);
Nada Dimitrijevic, Downers Grove, IL (US);
Tamara Koritarov, Naperville, IL (US);
Tijana Rajh, Naperville, IL (US);
Elena A. Rozhkova, Lemont, IL (US);
Harry C. Fry, Lincolnwood, IL (US);
Nada Dimitrijevic, Downers Grove, IL (US);
Tamara Koritarov, Naperville, IL (US);
Bartosz Gryzbowski, Evanston, IL (US);
UChicago Argonne, LLC, Chicago, IL (US);
Abstract
A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.