The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Nov. 05, 2015
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
James Bradner, Cambridge, MA (US);
Kimberly Stegmaier, Jamaica Plain, MA (US);
Jun Qi, Sharon, MA (US);
Anthony Varca, Boston, MA (US);
Giovanni Roti, Brookline, MA (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/365 (2006.01); A61K 47/55 (2017.01); C07D 475/04 (2006.01); C07D 307/93 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
A61K 47/551 (2017.08); A61K 31/365 (2013.01); A61K 31/519 (2013.01); C07D 307/93 (2013.01); C07D 475/04 (2013.01);
Abstract
The invention relates to novel derivatives of thapsigargin that are chemically modified with a group that targets a cell surface-expressed receptor, and pharmaceutical preparations thereof. The invention further relates to methods of treating diseases such as cancer using the compounds of the invention.