The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Aug. 19, 2011
Mark Cragg, Southampton, GB;
Martin Glennie, Southampton, GB;
Ali Roghanian, Southampton, GB;
Stephen Beers, Southampton, GB;
Peter Johnson, Southampton, GB;
Sean Lim, Southampton, GB;
Bjorn Frendeus, Landskorna, SE;
Ingrid Teige, Lund, SE;
Mark Cragg, Southampton, GB;
Martin Glennie, Southampton, GB;
Ali Roghanian, Southampton, GB;
Stephen Beers, Southampton, GB;
Peter Johnson, Southampton, GB;
Sean Lim, Southampton, GB;
Bjorn Frendeus, Landskorna, SE;
Ingrid Teige, Lund, SE;
University of Southampton, Southampton, GB;
Abstract
The invention provides a method of treating a patient having target cells that express FcyRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcyRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcyRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcyRIIb.