The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Dec. 16, 2015
Idenix Pharmaceuticals Llc, Cambridge, MA (US);
Universita Degli Studi Di Cagliari, Cagliari, IT;
Jean-Pierre Sommadossi, Boston, MA (US);
Paolo La Colla, Capoterra, IT;
David N. Standring, Milton, MA (US);
Vadim Bichko, San Diego, CA (US);
Lin Qu, Webster, TX (US);
Idenix Pharmaceuticals LLC, Cambridge, MA (US);
Universita Degli Studi Di Cagliari, Cagliari, IT;
Abstract
The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2'-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.