The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Aug. 14, 2015
Applicants:
The Johns Hopkins University, Baltimore, MD (US);
Kennedy Krieger Institute, Inc., Baltimore, MD (US);
Inventor:
Shilpa D. Kadam, Pikesville, MD (US);
Assignees:
The Johns Hopkins University, Baltimore, MD (US);
Kennedy Krieger Institute, Inc., Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4015 (2006.01); A61K 31/501 (2006.01); A61K 31/196 (2006.01); A61K 45/06 (2006.01); A61K 31/4166 (2006.01); A61K 31/515 (2006.01); A61K 31/553 (2006.01); A61K 31/55 (2006.01); A61K 38/08 (2019.01);
U.S. Cl.
CPC ...
A61K 31/196 (2013.01); A61K 31/4015 (2013.01); A61K 31/4166 (2013.01); A61K 31/501 (2013.01); A61K 31/515 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 38/08 (2013.01); A61K 45/06 (2013.01); A01K 2207/20 (2013.01); A01K 2207/30 (2013.01); A01K 2267/0356 (2013.01);
Abstract
The present invention relates to the field of seizures. More specifically, the present invention provides compositions and methods for treating refractory seizures in neonates. In one embodiment, the method comprises the steps of (a) administering to the patient an amount of a KCC2 agonist and/or trkB antagonist effective to restore KCC2 expression to normal physiological levels; and (b) administering to the patient an effective amount of an anti-seizure medication.