The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 07, 2020

Filed:

Jul. 11, 2018
Applicant:

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Omid Farokhzad, Waban, MA (US);

Jun Wu, Boston, MA (US);

Lili Zhao, Boston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 9/50 (2006.01); A61K 9/00 (2006.01); A61K 47/60 (2017.01); A61K 47/59 (2017.01); A61K 47/64 (2017.01); A61K 47/69 (2017.01); A61K 38/38 (2006.01); A61K 38/28 (2006.01); C08G 81/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5153 (2013.01); A61K 9/0019 (2013.01); A61K 9/5073 (2013.01); A61K 9/5078 (2013.01); A61K 9/5192 (2013.01); A61K 38/28 (2013.01); A61K 38/38 (2013.01); A61K 38/385 (2013.01); A61K 47/593 (2017.08); A61K 47/60 (2017.08); A61K 47/645 (2017.08); A61K 47/6931 (2017.08); A61K 47/6937 (2017.08); C08G 81/00 (2013.01);
Abstract

Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (α-amino acid)-α,ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.


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