The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
May. 22, 2017
Southern Medical University, Guangzhou, CN;
Macau University of Science and Technology, Taipa, MO;
Jin-Xiang Chen, Guangzhou, CN;
Bao-Ping Xie, Guangzhou, CN;
Gui-Hua Qiu, Guangzhou, CN;
Pei-Pei Hu, Guangzhou, CN;
Zhen Liang, Guangzhou, CN;
Ye-Mei Liang, Guangzhou, CN;
Bin Sun, Guangzhou, CN;
Li-Ping Bai, Taipa, MO;
Zhi-Hong Jiang, Taipa, MO;
MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY, Taipa, MO;
SOUTHERN MEDICAL UNIVERSITY, Guangzhou, CN;
Abstract
A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.