The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
Mar. 13, 2017
Applicant:
Ares Trading S.a., Aubonne, CH;
Inventors:
Thomas Solacroup, Blonay, CH;
Matthieu Stettler, Vucherens, CH;
Martin Jordan, Ecublens, CH;
Hervé Broly, Chatel-St Denis, CH;
Assignee:
ARES TRADING S.A., Aubonne, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/96 (2006.01); C07K 16/00 (2006.01); C12P 21/06 (2006.01); C12P 21/04 (2006.01); C12P 21/00 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 16/241 (2013.01); C07K 2317/14 (2013.01); C07K 2317/41 (2013.01); C07K 2317/515 (2013.01); C12N 2500/12 (2013.01);
Abstract
The present invention relates to a cell culture method for adjusting the proportion of G0, G1, G2, and high-mannose galactosylation variants in a population of a recombinant protein produced by a culture of cells in a cell culture medium by supplementing the cell culture medium with manganese at one or more days of the cell culture method duration.