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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10519418 B1

PDFFull Text
Date of Patent:
Dec. 31, 2019

Filed:

Apr. 23, 2018

Modified gram positive bacteria and uses thereof

Applicant:

Intrexon Actobiotics NV, Zwijnaarde, BE;

Inventors:

Lothar Steidler, Lokeren, BE;

Karolien Van Huynegem, Asper, BE;

Klaas Vandenbroucke, De Pinte, BE;

Assignee:

INTREXON ACTOBIOTICS NV, Zwijnaarde, BE;

Attorney:

Drinker Biddle & Reath LLP

Primary Examiner:

Padmavathi Baskar

Int. Cl.
CPC ...
C12N 1/04 (2006.01); C12N 1/20 (2006.01); C12N 9/10 (2006.01); C07K 14/315 (2006.01); A23L 33/135 (2016.01); A23C 9/123 (2006.01); A23K 10/18 (2016.01); C12P 19/12 (2006.01); C12N 9/16 (2006.01); A61K 39/00 (2006.01); C12R 1/01 (2006.01); C12R 1/225 (2006.01);
U.S. Cl.
CPC ...
C12N 1/20 (2013.01); A23C 9/1234 (2013.01); A23K 10/18 (2016.05); A23L 33/135 (2016.08); C07K 14/315 (2013.01); C12N 1/04 (2013.01); C12N 9/1051 (2013.01); C12N 9/16 (2013.01); C12P 19/12 (2013.01); A23Y 2220/00 (2013.01); A23Y 2300/00 (2013.01); A61K 2039/523 (2013.01); C12R 1/01 (2013.01); C12R 1/225 (2013.01); C12Y 204/01216 (2013.01); Y02P 20/52 (2015.11);
Abstract

The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC)activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP)activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.

Find Patent Forward Citations

Steidler, Lothar. (2019). Modified gram positive bacteria and uses thereof (U.S. Patent No. 10519418). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10519418

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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