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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10519250 B1

PDFFull Text
Date of Patent:
Dec. 31, 2019

Filed:

Aug. 01, 2017

Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof

Applicant:

Xoma (Us) Llc, Berkeley, CA (US);

Inventors:

Raphael D. Levy, Berkeley, CA (US);

Hassan Issafras, Berkeley, CA (US);

Agnes Choppin Holmes, Berkeley, CA (US);

Kirk W. Johnson, Berkeley, CA (US);

Amer M. Mirza, Berkeley, CA (US);

Daniel H. Bedinger, Berkeley, CA (US);

Rachel A. Hunt, Berkeley, CA (US);

Toshihiko Takeuchi, Berkeley, CA (US);

Kiranjit Kaur Ahluwalia, Berkeley, CA (US);

Robyn Cotter, Berkeley, CA (US);

Assignee:

XOMA (US) LLC, Emeryville, CA (US);

Attorney:

Marshall, Gerstein & Borun LLP

Primary Examiner:

Shulamith H Shafer

Int. Cl.
CPC ...
A61K 39/395 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01); C12P 21/06 (2006.01); C12P 19/34 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 16/44 (2006.01); A61K 38/02 (2006.01); C07K 16/26 (2006.01); A61K 39/00 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61K 38/02 (2013.01); A61K 39/00 (2013.01); A61K 39/395 (2013.01); A61K 39/39541 (2013.01); C07K 16/26 (2013.01); C07K 16/2869 (2013.01); C07K 2317/76 (2013.01); G01N 2333/635 (2013.01);
Abstract

The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.

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