The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
Jul. 01, 2016
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Ulrich Brinkmann, Weilheim, DE;
Eike Hoffmann, Herrsching a. Ammersee, DE;
Stefan Dengl, Munich, DE;
Klaus Mayer, Munich, DE;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/44 (2006.01); C07K 16/00 (2006.01); A61K 38/45 (2006.01); C07K 16/30 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61K 38/45 (2013.01); A61K 47/557 (2017.08); A61K 47/6817 (2017.08); A61K 47/6829 (2017.08); A61K 47/6835 (2017.08); A61K 47/6879 (2017.08); A61K 47/6893 (2017.08); C07K 16/00 (2013.01); C07K 16/3076 (2013.01); C12Y 204/02036 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/94 (2013.01);
Abstract
Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.