The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
May. 10, 2018
Janssen Pharmaceutica NV, New Brunswick, NJ (US);
Sergio-Alvar Alonso-de Diego, Toledo, ES;
Michiel Luc Maria Van Gool, Madrid, ES;
Maria Luz Martin-Martin, Toledo, ES;
Susana Conde-Ceide, Toledo, ES;
José Ignacio Andrés-Gil, Madrid, ES;
Óscar Delgado-González, Madrid, ES;
Gary John Tresadern, Toledo, ES;
Andrés Avelino Trabanco-Suárez, Toledo, ES;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ('mGluR2'). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.