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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10519146 B1

PDFFull Text
Date of Patent:
Dec. 31, 2019

Filed:

May. 21, 2018

Kras g12c inhibitors and methods of using the same

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Brian Alan Lanman, Thousand Oaks, CA (US);

Jian Chen, Thousand Oaks, CA (US);

Anthony B. Reed, Thousand Oaks, CA (US);

Victor J. Cee, Thousand Oaks, CA (US);

Longbin Liu, Thousand Oaks, CA (US);

David John Kopecky, Thousand Oaks, CA (US);

Patricia Lopez, Thousand Oaks, CA (US);

Ryan Paul Wurz, Thousand Oaks, CA (US);

Thomas T. Nguyen, Thousand Oaks, CA (US);

Shon Booker, Thousand Oaks, CA (US);

Nobuko Nishimura, Thousand Oaks, CA (US);

Youngsook Shin, Thousand Oaks, CA (US);

Nuria A. Tamayo, Thousand Oaks, CA (US);

John Gordon Allen, Thousand Oaks, CA (US);

Jennifer Rebecca Allen, Thousand Oaks, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:

Joseph F. Reidy

Primary Examiner:

Venkataraman Balasubramanian

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 403/04 (2006.01); C07D 401/04 (2006.01); C07D 475/00 (2006.01); A61K 31/496 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01); C07D 417/04 (2006.01); A61K 38/07 (2006.01); C07D 487/08 (2006.01); C07D 417/12 (2006.01); C07D 513/04 (2006.01); C07D 487/10 (2006.01); C07D 239/80 (2006.01); C07D 401/14 (2006.01); C07D 237/34 (2006.01); A61K 31/416 (2006.01); A61K 31/55 (2006.01); A61K 31/454 (2006.01); A61K 31/517 (2006.01); A61K 31/502 (2006.01); A61K 31/5025 (2006.01); A61K 31/7068 (2006.01); C07D 275/04 (2006.01);
U.S. Cl.
CPC ...
C07D 417/04 (2013.01); A61K 31/416 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01); A61K 31/7068 (2013.01); A61K 38/07 (2013.01); A61P 35/00 (2018.01); C07D 237/34 (2013.01); C07D 239/80 (2013.01); C07D 275/04 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 475/00 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 513/04 (2013.01);
Abstract

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

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