The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 31, 2019

Filed:

Nov. 10, 2014
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Tesfaye Biftu, Freehold, NJ (US);

Purakkattle Biju, Westwood, MA (US);

Steven L. Colletti, Princeton, NJ (US);

Qun Dang, Westfield, NJ (US);

Pawan Dhondi, Elizabeth, NJ (US);

Candido Gude, Staten Island, NY (US);

Hubert Josien, Jersey City, NJ (US);

Nam Fung Kar, Brooklyn, NY (US);

Anilkumar G. Nair, Edison, NJ (US);

Ravi P. Nargund, East Brunswick, NJ (US);

De-Yi Yang, Morris Plains, NJ (US);

Cheng Zhu, Edison, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/16 (2006.01); A61K 31/435 (2006.01); C07D 401/12 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); A61K 9/20 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 221/16 (2013.01); A61K 9/20 (2013.01); A61K 31/435 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01);
Abstract

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.


Find Patent Forward Citations

Loading…