The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
May. 06, 2014
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Labros Meimetis, Somerville, MA (US);
Jonathan Carlson, Jamaica Plain, MA (US);
Ralph Weissleder, Peabody, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); A61K 49/00 (2006.01); C07F 5/02 (2006.01); C07D 405/10 (2006.01); C07D 455/03 (2006.01); C07D 491/052 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0052 (2013.01); A61K 49/0021 (2013.01); A61K 49/0039 (2013.01); A61K 49/0056 (2013.01); A61K 49/0058 (2013.01); C07D 405/10 (2013.01); C07D 455/03 (2013.01); C07D 491/052 (2013.01); C07F 5/022 (2013.01);
Abstract
This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging.