The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
Oct. 04, 2017
Applicants:
Zymeworks Inc., Vancouver, CA;
Var2 Pharmaceuticals Aps, Copenhagen N, DK;
Inventors:
John Babcook, Vancouver, CA;
James R. Rich, Vancouver, CA;
Mads Daugaard, Vancouver, CA;
Ali El-Salanti, Farum, DK;
Assignees:
ZYMEWORKS INC., Vancouver, CA;
VAR2 PHARMACEUTICALS APS, København, DK;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/64 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01); A61K 38/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6425 (2017.08); A61K 38/06 (2013.01); A61K 47/64 (2017.08); A61K 47/65 (2017.08); A61P 35/00 (2018.01);
Abstract
VAR2CSA-drug conjugates for targeting and inhibiting the growth of cancer cells that have developed resistance to a platinum drug and the use of the conjugates in the treatment of platinum drug-resistant cancers. VAR2CSA-drug conjugates (VDCs) comprise a VAR2CSA polypeptide that is capable of binding to oncofetal chondroitin sulfate (ofCS) and one or more toxins having anti-cancer activity conjugated to the VAR2CSA polypeptide, either directly or via a linker.