The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 31, 2019

Filed:

Sep. 29, 2017
Applicant:

Warsaw Orthopedic, Inc., Warsaw, IN (US);

Inventors:

Josee Roy, Germantown, TN (US);

Susan J. Drapeau, Cordova, TN (US);

Jeffrey C. Marx, Germantown, TN (US);

Assignee:

Warsaw Orthopedic, Inc., Warsaw, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); C07K 14/47 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61K 38/17 (2006.01); G01N 33/53 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); C07K 16/22 (2006.01); A61K 31/225 (2006.01); A61K 38/48 (2006.01); C07K 14/48 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1825 (2013.01); A61K 38/185 (2013.01); A61K 38/1858 (2013.01); A61K 38/2093 (2013.01); A61K 38/212 (2013.01); A61K 31/225 (2013.01); A61K 38/179 (2013.01); A61K 38/18 (2013.01); A61K 38/4893 (2013.01); A61K 39/3955 (2013.01); A61K 2039/505 (2013.01); A61K 2300/00 (2013.01); C07K 14/48 (2013.01); C07K 16/22 (2013.01); C07K 16/2863 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/52 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C12Y 304/24069 (2013.01);
Abstract

The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.


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