The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2019
Filed:
Jan. 26, 2017
Wuhan Ll Science and Technology Development Co., Ltd., Wuhan, Hubei, CN;
Wuhan Qr Pharmaceuticals Co., Ltd., Wuhan, Hubei, CN;
Jun Lou, Hubei, CN;
Penggao Yu, Hubei, CN;
Li Liu, Hubei, CN;
Hongwei Tang, Hubei, CN;
Anxiao Zheng, Hubei, CN;
Yongkai Chen, Hubei, CN;
Chaodong Wang, Hubei, CN;
WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD., Wuhan, CN;
WUHAN QR PHARMACEUTICALS CO., LTD., Wuhan, CN;
Abstract
The present disclosure provides a posaconazole derivative, a pharmaceutical composition and use thereof, which specifically include a compound represented by the following formula (I), a racemate, stereoisomer, tautomer, oxynitride, or a pharmaceutically acceptable salt thereof: The compounds of the present disclosure have strong antifungal activity, high safety, and good water solubility, without the need for the addition of a cosolvent (such as hydroxypropyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin, and the like) with potential safety risks. Furthermore, the formulation process of the compound could have less difficulty and less cost, and therefore can be used to prepare improved antifungal drugs.