The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2019
Filed:
Dec. 09, 2014
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Sohye Kang, Camarillo, CA (US);
Chung Huang, Jr., Newbury Park, CA (US);
Hedieh Barkhordarian, Moorpark, CA (US);
Pavel Bondarenko, Thousand Oaks, CA (US);
Zhongqi Zhang, Thousand Oaks, CA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C12N 5/071 (2010.01); C07K 14/52 (2006.01); C07K 16/00 (2006.01); C12N 1/38 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 14/52 (2013.01); C07K 16/00 (2013.01); C12N 1/38 (2013.01); C12N 5/0682 (2013.01); C07K 2317/14 (2013.01); C07K 2317/41 (2013.01); C12N 2500/32 (2013.01); C12N 2500/33 (2013.01); C12N 2500/46 (2013.01); C12N 2500/90 (2013.01); C12N 2510/02 (2013.01); C12N 2521/00 (2013.01);
Abstract
The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.