The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2019
Filed:
Dec. 02, 2016
Xiamen University, Xiamen, Fujian Province, CN;
Xiamen Innovax Biotech Co., Ltd., Xiamen, Fujian, CN;
Shaowei Li, Xiamen, CN;
Daning Wang, Xiamen, CN;
Xinlin Liu, Xiamen, CN;
Zhihai Li, Xiamen, CN;
Jun Zhang, Xiamen, CN;
Ningshao Xia, Xiamen, CN;
Xiamen University, Xiamen, Fujian Province, CN;
Xiamen Innovax Biotech Co., Ltd., Xiamen, Fujian, CN;
Abstract
Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.