The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2019
Filed:
Feb. 24, 2017
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Jianyan Xu, Shanghai, CN;
Ying Zhang, Shanghai, CN;
Bolei Qu, Shanghai, CN;
Guiyang Jiang, Shanghai, CN;
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Abstract
The present invention relates to a new toxin and a method for preparing an intermediate thereof. In particular, the present invention relates to a new toxin and a method for preparating intermediates of Formula (III) and Formula (IV) thereof, and a preparation method for synthesizing what is shown in general formula (I). The method comprises subjecting a chiral compound shown in general formula (III) to a series of protecting group additions, protecting group removal and amidation so as to obtain a compound as shown in general formula (I). The present method has the advantages of mild reaction conditions, simple operation, high optical purity and high synthetic yield, and thus is suitable for large-scale production.