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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10513504 B1

PDFFull Text
Date of Patent:
Dec. 24, 2019

Filed:

Mar. 06, 2019

Processes for the preparation of apalutamide and intermediates thereof

Applicant:

Apotex Inc., Toronto, CA;

Inventors:

Prabhudas Bodhuri, Torrance, CA (US);

Alfredo Paul Ceccarelli, Brantford, CA;

Michael R. Emmett, London, CA;

Avedis Karadeolian, Cambridge, CA;

Fabio E. S. Souza, Mississauga, CA;

Gamini Weeratunga, Ancaster, CA;

Boris Gorin, Oakville, CA;

Assignee:

Apotex Inc., Toronto, CA;

Attorney:

The Webb Law Firm

Primary Examiner:

Patricia L Morris

Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07C 231/12 (2006.01); C07D 249/04 (2006.01); C07D 207/40 (2006.01); C07D 233/56 (2006.01); C07C 237/30 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); C07C 231/12 (2013.01); C07C 237/30 (2013.01); C07D 207/40 (2013.01); C07D 233/56 (2013.01); C07D 249/04 (2013.01);
Abstract

The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).

Find Patent Forward Citations

Bodhuri, Prabhudas. (2019). Processes for the preparation of apalutamide and intermediates thereof (U.S. Patent No. 10513504). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10513504

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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