The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2019
Filed:
Aug. 27, 2015
Applicant:
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Inventors:
Thomas Reiner, Weehawken, NJ (US);
Jason S. Lewis, New York, NY (US);
Wolfgang Weber, Larchmont, NY (US);
Beatriz Salinas Rodriguez, Madrid, ES;
Brandon Carney, Brooklyn, NY (US);
Giuseppe Carlucci, New York, NY (US);
Assignee:
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); A61K 45/06 (2006.01); C07D 237/32 (2006.01); C07D 403/14 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0459 (2013.01); A61K 45/06 (2013.01); C07D 237/32 (2013.01); C07D 403/14 (2013.01); C07F 5/022 (2013.01);
Abstract
Disclosed are chemical entities of formula (I) wherein R, Rand n are defined herein, and methods of use thereof. These chemical entities are radiative emitters and are useful, e.g., as therapeutic agents for the treatment of, or as diagnostic (e.g., imaging) agents for cancers, e.g., cancers in which PARP1 is overexpressed.