The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2019
Filed:
Apr. 23, 2013
The Regents of the University of Michigan, Ann Arbor, MI (US);
Jerome Kalifa, Oak Park, MI (US);
Raoul Kopelman, Ann Arbor, MI (US);
Uma Mahesh R. Avula, Ypsilanti, MI (US);
Gwangseong Kim, Ann Arbor, MI (US);
Yong-eun Koo Lee, Seoul, KR;
Hyung Ki Yoon, Ann Arbor, MI (US);
Jerome Kalifa, Oak Park, MI (US);
Raoul Kopelman, Ann Arbor, MI (US);
Uma Mahesh R. Avula, Ypsilanti, MI (US);
Gwangseong Kim, Ann Arbor, MI (US);
Yong-Eun Koo Lee, Seoul, KR;
Hyung Ki Yoon, Ann Arbor, MI (US);
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Abstract
The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.