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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10512667 B1

PDFFull Text
Date of Patent:
Dec. 24, 2019

Filed:

Jun. 27, 2018

Compositions and methods for treating conditions related to adrenocortical activity and/or excessive steroid production

Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Tom K. Kerppola, Ann Arbor, MI (US);

Veronica E. Burns, Ann Arbor, MI (US);

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);

Attorneys:

Casimir Jones, SC

Robert Goetz

Primary Examiner:

Kevin E Weddington

Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61P 5/46 (2006.01); A61P 5/42 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 38/13 (2006.01); A61K 31/17 (2006.01); A61K 31/277 (2006.01); A61K 31/352 (2006.01); A61K 31/496 (2006.01); A61K 31/4965 (2006.01); A61K 31/5685 (2006.01); A61K 31/64 (2006.01); A61K 31/4725 (2006.01); A61K 31/18 (2006.01); A61K 35/04 (2006.01);
U.S. Cl.
CPC ...
A61K 38/12 (2013.01); A61K 31/17 (2013.01); A61K 31/277 (2013.01); A61K 31/352 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/4965 (2013.01); A61K 31/5685 (2013.01); A61K 31/64 (2013.01); A61K 38/13 (2013.01); A61K 45/06 (2013.01); A61P 5/42 (2018.01); A61P 5/46 (2018.01); A61P 35/00 (2018.01); A61K 31/18 (2013.01); A61K 35/04 (2013.01); A61K 2300/00 (2013.01);
Abstract

Provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production. In particular, provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production through administration of at least one of the following agents: 1) an agent capable of inhibiting cholesterol efflux related to ABCA1 and/or ABCG1; 2) an agent capable of inhibiting MDR1 related cortisol secretion and/or MDR1 P-glycoprotein multiple drug transporter activity; and 3) an agent capable of inhibiting mitochondrial activity.

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