The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2019
Filed:
Oct. 19, 2016
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Long Cai, Pasadena, CA (US);
Sheel Shah, Pasadena, CA (US);
Eric Lubeck, San Francisco, CA (US);
Wen Zhou, Pasadena, CA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C07H 21/00 (2006.01); G16B 25/00 (2019.01); G01N 21/78 (2006.01); G16B 40/00 (2019.01); C12Q 1/6841 (2018.01); G01N 21/64 (2006.01); C12Q 1/6881 (2018.01);
U.S. Cl.
CPC ...
G16B 25/00 (2019.02); C12Q 1/6841 (2013.01); G01N 21/6458 (2013.01); G01N 21/78 (2013.01); G16B 40/00 (2019.02); C12Q 1/6881 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Disclosed herein are methods and systems for detecting and/or quantifying cellular targets such as nucleic acids in cells, tissues, organs or organisms. Through sequential barcoding, it is possible to perform high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci. In some embodiments, error correction is implemented through use of barcodes that can tolerate mistakes and missing data during sequential hybridization of probes to selected targets.