The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 17, 2019

Filed:

Nov. 21, 2016
Applicant:

Hologic, Inc., Bedford, MA (US);

Inventors:

Erin Coffman, Nashua, NH (US);

Steven Hecht, Boston, MA (US);

Paul MacLean, Westborough, MA (US);

Assignee:

HOLOGIC, INC., Marlborough, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/34 (2006.01); A01N 1/00 (2006.01); G01N 1/28 (2006.01); C12N 5/071 (2010.01); C08L 33/08 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
G01N 1/34 (2013.01); A01N 1/00 (2013.01); C12N 5/0682 (2013.01); G01N 1/286 (2013.01); C08L 33/08 (2013.01); C12N 5/00 (2013.01);
Abstract

A wash solution for remediating lubricant contamination in cytological specimens includes a Tris-based alkaline buffer solution. The buffer solution may be prepared in methanol, and may include a proton-rich protein, or a basic amino acid, such as arginine, lysine, or guanidine. A method for remediating a specimen contaminated with lubricant includes using the wash solution and/or adding a salt to the final vial prior to preparing the microscope slide. The method may include adding the wash solution to the specimen, centrifuging the specimen and wash solution to form a supernatant and cell pellet, decanting the supernatant, and adding a preservative solution to the cell pellet. The method may further include adding salt to a vial containing the preservative solution and cell pellet.


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