The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2019
Filed:
Aug. 19, 2016
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Douglas A. Treco, Arlington, MA (US);
Alonso Ricardo, Boston, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C40B 40/08 (2006.01); C40B 50/06 (2006.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
C12N 15/1062 (2013.01); A61K 47/549 (2017.08); A61K 47/64 (2017.08); C40B 40/08 (2013.01); C40B 50/06 (2013.01);
Abstract
Provided herein are, inter alia, methods for linking an mRNA molecule to a polypeptide (e.g., a peptide or a protein) by linking the mRNA molecule to a linking amino acid in the polypeptide, or by linking the mRNA molecule to a linking tRNA to which the polypeptide is attached, via reactions not catalyzed by the ribosome, and methods for making polypeptide libraries. Also provided are mRNA-protein complexes and mRNA-tRNA-protein complexes, libraries containing these complexes, and methods of using these complexes.