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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10508130 B1

PDFFull Text
Date of Patent:
Dec. 17, 2019

Filed:

May. 10, 2017

Crystalline polymorph of 15b-hydroxy-osaterone acetate

Applicant:

Aska Pharmaceutical Co., Ltd., Tokyo, JP;

Inventors:

Takayoshi Nakagawa, Kanagawa, JP;

Hiroyuki Hayashi, Kanagawa, JP;

Koichi Miyazaki, Kanagawa, JP;

Shigeki Iwashita, Kanagawa, JP;

Assignee:

ASKA PHARMACEUTICAL CO., LTD., Tokyo, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Sun Jae Yoo

Int. Cl.
CPC ...
A61P 17/08 (2006.01); A61P 17/14 (2006.01); A61P 17/02 (2006.01); A61P 15/00 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); C07J 73/00 (2006.01);
U.S. Cl.
CPC ...
C07J 73/003 (2013.01); A61P 15/00 (2018.01); A61P 17/02 (2018.01); A61P 17/08 (2018.01); A61P 17/14 (2018.01); A61P 19/10 (2018.01); A61P 35/00 (2018.01); C07B 2200/13 (2013.01);
Abstract

Provided is a crystalline polymorphic form A of 15β-hydroxy-osaterone acetate having an improved stability (storage stability, pulverization stability, and absorption characteristics). In a powder X-ray diffraction spectrum, characteristic diffraction peaks of the crystalline polymorphic form A of 15β-hydroxy-osaterone acetate appear at diffraction angles 2θ of 9.6°±0.2°, 17.1°±0.2°, and 20.2°±0.2°. The crystalline polymorphic form A has a melting point of 280 to 283° C. and is a prism crystal.

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