The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2019
Filed:
Dec. 01, 2015
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Christian Fischer, Boston, MA (US);
Stephane L. Bogen, Rahway, NJ (US);
Matthew L. Childers, Boston, MA (US);
Francesc Xavier Fradera Llinas, Boston, MA (US);
J. Michael Ellis, Boston, MA (US);
Sara Esposite, Neptune, NJ (US);
Dawn M. Hoffman, Boston, MA (US);
Chunhui Huang, Kenilworth, NJ (US);
Solomon D. Kattar, Boston, MA (US);
Alexander J. Kim, Rahway, NJ (US);
John W. Lampe, Cary, NJ (US);
Michelle R. Machacek, Boston, MA (US);
Daniel R. McMasters, Boston, MA (US);
Dann L. Parker, Jr., Rahway, NJ (US);
Michael H. Reutershan, Boston, MA (US);
Nunzio Sciammetta, Boston, MA (US);
Pengcheng P. Shao, Fanwood, NJ (US);
David L. Sloman, Boston, MA (US);
Wanying Sun, Kenilworth, NJ (US);
Feroze Ujjainwalla, Kenilworth, NJ (US);
Zhicai Wu, Kenilworth, NJ (US);
Yang Yu, Kenilworth, NJ (US);
Craig R. Gibeau, Boston, MA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is —C(R)═ or —N═; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.