The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 17, 2019

Filed:

Aug. 16, 2018
Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

P. Jeffrey Conn, Brentwood, TN (US);

Craig W. Lindsley, Brentwood, TN (US);

Andrew S. Felts, Brentwood, TN (US);

Colleen M. Niswender, Brentwood, TN (US);

Rory A. Capstick, Nashville, TN (US);

Paul K. Spearing, Chapel Hill, TN (US);

Sean R. Bollinger, Murfeesboro, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 407/14 (2006.01); C07D 409/14 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61P 25/00 (2018.01); C07D 401/12 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.


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