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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10508090 B1

PDFFull Text
Date of Patent:
Dec. 17, 2019

Filed:

Aug. 07, 2017

Sulfonamides as gpr40- and gpr120-agonists

Applicant:

Dompé Farmaceutici S.p.a., Milan, IT;

Inventors:

Maria De Pizzol, Milan, IT;

Anna Sirico, Somma Vesuviana, IT;

Mara Zippoli, Genoa, IT;

Gianluca Bianchini, L'Aquila, IT;

Andrea Beccari, L'Aquila, IT;

Andrea Aramini, L'Aquila, IT;

Chiara Rossana Maria Liberati, Milan, IT;

Assignee:

DOMPÉ FARMACEUTICI S.P.A., Milan, IT;

Attorney:

Hueschen and Sage

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07C 311/16 (2006.01); C07C 311/20 (2006.01); C07C 311/21 (2006.01); C07C 311/51 (2006.01); C07D 231/42 (2006.01); C07D 235/30 (2006.01); C07D 249/04 (2006.01); C07D 249/08 (2006.01); C07D 249/14 (2006.01); C07D 257/06 (2006.01); C07D 261/16 (2006.01); C07D 263/30 (2006.01); C07D 275/03 (2006.01); C07D 277/52 (2006.01); C07D 285/04 (2006.01); C07D 285/135 (2006.01); C07D 263/50 (2006.01); C07D 263/28 (2006.01); C07D 285/08 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
C07D 285/135 (2013.01); C07C 311/16 (2013.01); C07C 311/20 (2013.01); C07C 311/21 (2013.01); C07C 311/51 (2013.01); C07D 231/42 (2013.01); C07D 235/30 (2013.01); C07D 249/04 (2013.01); C07D 249/08 (2013.01); C07D 249/14 (2013.01); C07D 257/06 (2013.01); C07D 261/16 (2013.01); C07D 263/28 (2013.01); C07D 263/30 (2013.01); C07D 263/50 (2013.01); C07D 275/03 (2013.01); C07D 277/52 (2013.01); C07D 285/04 (2013.01); C07D 285/08 (2013.01); A61P 3/04 (2018.01); A61P 3/06 (2018.01); A61P 3/10 (2018.01);
Abstract

The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.

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