The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 17, 2019

Filed:

Mar. 18, 2018
Applicants:

Minhua Chen, Scotch Plains, NJ (US);

Yanfeng Zhang, Suzhou, CN;

Chaohui Yang, Suzhou, CN;

Xiaoyu Zhang, Suzhou, CN;

Inventors:

Minhua Chen, Scotch Plains, NJ (US);

Yanfeng Zhang, Suzhou, CN;

Chaohui Yang, Suzhou, CN;

Xiaoyu Zhang, Suzhou, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 257/04 (2006.01); A61K 31/225 (2006.01); A61K 31/41 (2006.01); C07C 233/47 (2006.01);
U.S. Cl.
CPC ...
C07D 257/04 (2013.01); A61K 31/225 (2013.01); A61K 31/41 (2013.01); C07C 233/47 (2013.01); C07B 2200/13 (2013.01);
Abstract

Novel crystalline forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.


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