The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 17, 2019

Filed:

Feb. 12, 2014
Applicants:

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (US);

The United States Goverment, As Represented BY the Secretary of the Army, U.s.a., Fort Detrick, MD (US);

The Government of the United States of America As Represented BY the Secretary of the Department of Health and Human Services, Rockville, MD (US);

Inventors:

Wesley M. Jackson, Albany, CA (US);

Leon J. Nesti, Silver Spring, MD (US);

Rocky S. Tuan, Bethesda, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2015.01); A61K 9/70 (2006.01); A61F 2/02 (2006.01); C12N 5/0775 (2010.01); A61L 27/18 (2006.01); A61L 27/34 (2006.01); A61L 27/38 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01); A61L 27/54 (2006.01); A61K 35/28 (2015.01); A61K 45/06 (2006.01); A61F 2/06 (2013.01);
U.S. Cl.
CPC ...
A61K 9/70 (2013.01); A61F 2/02 (2013.01); A61K 35/28 (2013.01); A61K 45/06 (2013.01); A61L 27/18 (2013.01); A61L 27/34 (2013.01); A61L 27/3834 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); C12N 5/0663 (2013.01); C12N 5/0668 (2013.01); A61F 2/062 (2013.01); A61F 2210/0004 (2013.01); A61F 2250/0067 (2013.01); A61K 2035/124 (2013.01); A61L 2400/12 (2013.01); A61L 2430/32 (2013.01); C12N 2500/40 (2013.01); C12N 2500/44 (2013.01); C12N 2501/01 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/13 (2013.01); C12N 2501/235 (2013.01); C12N 2501/33 (2013.01); C12N 2501/385 (2013.01); C12N 2501/39 (2013.01); C12N 2533/40 (2013.01);
Abstract

A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.


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