The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Nov. 12, 2015
Applicant:
Waters Technologies Corporation, Milford, MA (US);
Inventors:
Michael F. Morris, Ashland, MA (US);
Matthew A. Lauber, North Smithfield, RI (US);
Darryl W. Brousmiche, Grafton, MA (US);
Assignee:
Waters Technologies Corporation, Milford, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 30/00 (2006.01); G01N 30/02 (2006.01); C07D 215/48 (2006.01); G01N 30/04 (2006.01); B01D 15/30 (2006.01); C07H 15/26 (2006.01); G01N 30/88 (2006.01); G01N 33/68 (2006.01); G01N 30/62 (2006.01);
U.S. Cl.
CPC ...
G01N 30/02 (2013.01); B01D 15/305 (2013.01); C07D 215/48 (2013.01); C07H 15/26 (2013.01); G01N 30/04 (2013.01); G01N 30/88 (2013.01); G01N 33/6842 (2013.01); G01N 2030/027 (2013.01); G01N 2030/047 (2013.01); G01N 2030/626 (2013.01); G01N 2030/8836 (2013.01); G01N 2400/00 (2013.01); G01N 2440/38 (2013.01);
Abstract
Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.