The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 10, 2019

Filed:

May. 30, 2018
Applicant:

Life Technologies Corporation, Carlsbad, CA (US);

Inventors:

Jonathan Rothberg, Guilford, CT (US);

Wolfgang Hinz, Carlsbad, CA (US);

Kim Johnson, Carlsbad, CA (US);

James Bustillo, Castro Valley, CA (US);

Assignee:

LIFE TECHNOLOGIES CORPORATION, Carlsbad, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/403 (2006.01); G01N 27/414 (2006.01); C12Q 1/6874 (2018.01); H01L 29/78 (2006.01); H01L 27/088 (2006.01); C12Q 1/6818 (2018.01); G01N 33/543 (2006.01); H01L 29/423 (2006.01);
U.S. Cl.
CPC ...
G01N 27/4148 (2013.01); C12Q 1/6818 (2013.01); C12Q 1/6874 (2013.01); G01N 27/4145 (2013.01); G01N 33/5438 (2013.01); G01N 33/54373 (2013.01); H01L 27/088 (2013.01); H01L 29/78 (2013.01); H01L 29/42324 (2013.01); H01L 2924/01006 (2013.01); H01L 2924/01013 (2013.01); H01L 2924/01015 (2013.01); H01L 2924/01073 (2013.01); H01L 2924/14 (2013.01); H01L 2924/1433 (2013.01); Y10T 436/22 (2015.01);
Abstract

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.


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