The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Apr. 03, 2015
Crown Bioscience, Inc. (Taicang), Taicang, Jiangsu, CN;
Sheng Guo, Jiangsu, CN;
Wubin Qian, Jiangsu, CN;
Jinying Ning, Jiangsu, CN;
Jing Zhang, Jiangsu, CN;
Jixian Li, Jiangsu, CN;
Zhu Mei, Jiangsu, CN;
CROWN BIOSCIENCE, INC. (TAICANG), Taicang Jiangsu, CN;
Abstract
A method for predicting the responsiveness of a cancer cell to an MEK inhibitor, comprising detecting the presence of at least one mutation in one or more genes selected from the group consisting of ADAM12, COL14A1, TNN, and TP53, in the cancer cell, by contacting a nucleic acid sample derived from the cancer cell with at least one oligonucleotide which allows specific detection of the mutation; wherein presence of mutation in ADAM12, COL14A1, TNN, TP53 and/or any combination thereof is indicative of decreased responsiveness of the cancer cell to the ERK inhibitor.