The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Nov. 21, 2016
Rqx Pharmaceuticals, Inc., La Jolla, CA (US);
Tucker Curran Roberts, San Diego, CA (US);
Peter Andrew Smith, La Jolla, CA (US);
David Campbell, San Diego, CA (US);
Sergio G. Duron, San Diego, CA (US);
Robert I. Higuchi, Solana Beach, CA (US);
RQX PHARMACEUTICALS, INC., San Diego, CA (US);
Abstract
Provided herein are analogs of the natural product arylomycin for the treatment of microbial infections. In some embodiments, the compounds described herein have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.