The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Jun. 23, 2016
University Health Network, Toronto, CA;
Peter Brent Sampson, Oakville, CA;
Narendra Kumar B. Patel, Brampton, CA;
Heinz W. Pauls, Oakville, CA;
Sze-Wan Li, Toronto, CA;
Grace Ng, Markham, CA;
Radoslaw Laufer, Oakville, CA;
Yong Liu, Oakville, CA;
Yunhui Lang, Markham, CA;
University Health Network, Toronto, CA;
Abstract
Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X; X, and Xis S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).