The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Feb. 26, 2018
Dart Neuroscience (Cayman) Ltd., Grand Cayman, KY;
James Breitenbucher, Escondido, CA (US);
Graeme Freestone, San Diego, CA (US);
Laurent Gomez, San Diego, CA (US);
Robert Lemus, Escondido, CA (US);
Kiev Ly, San Diego, CA (US);
Margaret McCarrick, San Diego, CA (US);
William Vernier, Vista, CA (US);
Troy Vickers, San Diego, CA (US);
Dart Neuroscience (Cayman) Ltd., Grand Cayman, KY;
Abstract
The invention provides a chemical entity of Formula (I): wherein R, R, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.