The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Jan. 27, 2017
Applicant:
Vanderbilt University, Nashville, TN (US);
Inventors:
Steve Fesik, Nashville, TN (US);
Alex Waterson, Murfreesboro, TN (US);
Michael Burns, Chicago, IL (US);
Qi Sun, Vernon Hills, IL (US);
Jason Phan, Nashville, TN (US);
James M. Salovich, Nashville, TN (US);
Jason R. Abbott, Nashville, TN (US);
Andrew Little, Boston, MA (US);
Assignee:
Vanderbilt University, Nashville, TN (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 235/30 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 235/30 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/04 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01);
Abstract
Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.