The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Mar. 23, 2016
Applicants:
University of Miami, Miami, FL (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Inventors:
Anthony J. Capobianco, Miami, FL (US);
Alex Mackerell, Jr., Baltimore, MD (US);
Mark Spyvee, Hampstead, NH (US);
Assignees:
UNIVERSITY OF MIAMI, Miami, FL (US);
UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/444 (2006.01); A61K 31/4015 (2006.01); A61K 31/426 (2006.01); C07D 277/54 (2006.01); C07D 277/36 (2006.01);
U.S. Cl.
CPC ...
C07D 207/444 (2013.01); A61K 31/4015 (2013.01); A61K 31/426 (2013.01); C07D 277/36 (2013.01); C07D 277/54 (2013.01);
Abstract
Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.