The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Aug. 22, 2017
The University Court of the University of Aberdeen, Aberdeen, GB;
The University Court of the University of St. Andrews, St. Andrews, GB;
Wael Houssen Ibrahim, Aberdeen, GB;
Marcel Jaspars, Aberdeen, GB;
Margaret Smith, Aberdeen, GB;
James Naismith, St. Andrews, GB;
Jesko Koehnke, St. Andrews, GB;
Andrew Bent, St. Andrews, GB;
Nicholas Westwood, St. Andrews, GB;
Oxford University Innovation Limited, Oxford, GB;
Abstract
This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG fromspp. Before cyclization, residues in the linear peptide substrates may be heterocyclized using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.