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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10494606 B1

PDFFull Text
Date of Patent:
Dec. 03, 2019

Filed:

Jun. 26, 2017

Immortalized stem cell, compositions, preparations and uses thereof

Applicant:

Quarrymen & Co. Inc., Tokyo, JP;

Inventor:

Minoru Ueda, Tokyo, JP;

Assignee:

QUARRYMEN&Co. Inc., Tokyo, JP;

Attorneys:

Locke Lord LLP

James E. Armstrong, IV

Andrew W. Smith

Primary Examiner:

Maria G Leavitt

Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/0775 (2010.01); C12N 5/074 (2010.01); A61K 38/18 (2006.01); A61K 38/30 (2006.01); A61K 35/28 (2015.01); A61K 35/32 (2015.01); A61K 35/54 (2015.01); A61K 9/00 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0664 (2013.01); A61K 9/0014 (2013.01); A61K 9/0043 (2013.01); A61K 35/28 (2013.01); A61K 35/32 (2013.01); A61K 35/54 (2013.01); A61K 38/1833 (2013.01); A61K 38/1841 (2013.01); A61K 38/1866 (2013.01); A61K 38/30 (2013.01); C12N 5/0696 (2013.01); C12N 15/85 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2506/1346 (2013.01); C12N 2506/1361 (2013.01);
Abstract

The purpose of the present invention is to provide immortalized stem cells, which produce a growth factor capable of regenerating various kinds of tissues that have been damaged by a variety of causes, and a method for producing the aforesaid immortalized stem cells. Another purpose is to provide a medicinal composition and a medicinal preparation for restoring damaged tissues, and a method for the percutaneous absorption of a culture supernatant. Provided are immortalized stem cells that are obtained by isolating stem cells selected from the group consisting of mammalian mesenchymal cells, an embryo at the early stage of the development and somatic cells, first culturing the cells to give first stage culture cells, transferring four kinds of genes into the first stage culture cells to give transgenic cells, and selecting the desired immortalized stem cells from among the transgenic cells using the expression of STRO-1 as an index.

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